Single Enzyme SGPT Estimation is a Cheap and Reliable Prognostic Indicator for Organ Phosphorus Poisoning Cases

This study defines the laboratory investigations and the outcome in acute organophosphate poisoning patients admitted to medicine indoor department of R G Kar Medical College and Hospital, Kolkata 700004, India. Out of 276 OP poisoning patients, it was noticed that suicidal and intentional poisoning being a major cause as recorded in most cases.58 patients could not survive during the treatment. The cases were selected with definite history of OP poisoning coming with poison samples with major signs and symptoms seen by the physicians which were mostly muscarinic and nicotinic manifestations. The activities of serum Total Bilirubin, Direct bilirubin, SGPT, SGOT and ALP parameters of liver function test were estimated and found to be significantly elevated (p≤0.01) in all the poisoning cases indicating muscular functional impairment due to OP toxicity. But the SGPT levels are highly elevated in dead subjectscompared to the survived one and found statistically significant(p≤0.01). Multiple regression analysis showed that the survival rate of the cases was more among the cases with a high serum SGPT. The findings of this study reflect the usefulness of serum SGPT in the management of OP pesticide poisoning and a good prognostic indicator of survival.